Two-Wave Mixing in Organic-Inorganic Hybrid Structures for Dynamic Holography

The chapter reviews recent progress of two-wave mixing in a novel organic-inorganic hybrid structures that combine essential properties as large anisotropy and strong birefringence, typical for organics with the excellent photosensitivity and photoconductivity of inorganics into single, compact devices. Depending on the designed assembly and operation principle, the proposed structures can record dynamic holographic gratings at Raman-Nath or Bragg regimes of diffraction, respectively. When the two beams interact in a structure based on a photoconductive material and birefringent layer (usually liquid crystal), the beam coupling with high amplification values occur in a liquid crystal layer, however, the fringe period of recorded holograms is limited to few μm scale. In contrast, when the two beams interact in a structure based on a photorefractive material and birefringent layer, the beam-coupling occurs in both composites, due to the surface activated photorefractive effect. The prime significance of the later structure is the ability to act as a holographic grating at Bragg regime allowing sub-micron spatial resolution. Moreover they are easy and simple to fabricate where the processes are all optically controlled. The above examples open scenarios to design new devices that meet the latest requirements of 3D display technologies and optical information processing

Identification of novel DNA methylation inhibitors via a two-component reporter gene system

<p>Abstract</p> <p>Background</p> <p>Targeting abnormal DNA methylation represents a therapeutically relevant strategy for cancer treatment as demonstrated by the US Food and Drug Administration approval of the DNA methyltransferase inhibitors azacytidine and 5-aza-2'-deoxycytidine for the treatment of myelodysplastic syndromes. But their use is associated with increased incidences of bone marrow suppression. Alternatively, procainamide has emerged as a potential DNA demethylating agent for clinical translation. While procainamide is much safer than 5-aza-2'-deoxycytidine, it requires high concentrations to be effective in DNA demethylation in suppressing cancer cell growth. Thus, our laboratories have embarked on the pharmacological exploitation of procainamide to develop potent DNA methylation inhibitors through lead optimization.</p> <p>Methods</p> <p>We report the use of a DNA methylation two-component enhanced green fluorescent protein reporter system as a screening platform to identify novel DNA methylation inhibitors from a compound library containing procainamide derivatives.</p> <p>Results</p> <p>A lead agent IM25, which exhibits substantially higher potency in <it>GSTp1 </it>DNA demethylation with lower cytotoxicity in MCF7 cells relative to procainamide and 5-aza-2'-deoxycytidine, was identified by the screening platform.</p> <p>Conclusions</p> <p>Our data provide a proof-of-concept that procainamide could be pharmacologically exploited to develop novel DNA methylation inhibitors, of which the translational potential in cancer therapy/prevention is currently under investigation.</p

Kinematic strategies for obstacle-crossing in older adults with mild cognitive impairment

IntroductionMild cognitive impairment (MCI) is considered a transitional stage between soundness of mind and dementia, often involving problems with memory, which may lead to abnormal postural control and altered end-point control when dealing with neuromechanical challenges during obstacle-crossing. The study aimed to identify the end-point control and angular kinematics of the pelvis-leg apparatus while crossing obstacles for both leading and trailing limbs.Methods12 patients with MCI (age: 66.7 ± 4.2 y/o; height: 161.3 ± 7.3 cm; mass: 62.0 ± 13.6 kg) and 12 healthy adults (age: 67.7 ± 2.9 y/o; height: 159.3 ± 6.1 cm; mass: 61.2 ± 12.0 kg) each walked and crossed obstacles of three different heights (10, 20, and 30% of leg length). Angular motions of the pelvis and lower limbs and toe-obstacle clearances during leading- and trailing-limb crossings were calculated. Two-way analyses of variance were used to study between-subject (group) and within-subject (obstacle height) effects on the variables. Whenever a height effect was found, a polynomial test was used to determine the trend. A significance level of α = 0.05 was set for all tests.ResultsPatients with MCI significantly increased pelvic anterior tilt, hip abduction, and knee adduction in the swing limb during leading-limb crossing when compared to controls (p &lt; 0.05). During trailing-limb crossing, the MCI group showed significantly decreased pelvic posterior tilt, as well as ankle dorsiflexion in the trailing swing limb (p &lt; 0.05).ConclusionPatients with MCI adopt altered kinematic strategies for successful obstacle-crossing. The patients were able to maintain normal leading and trailing toe-obstacle clearances for all tested obstacle heights with a specific kinematic strategy, namely increased pelvic anterior tilt, swing hip abduction, and knee adduction during leading-limb crossing, and decreased pelvic posterior tilt and swing ankle dorsiflexion during trailing-limb crossing. The current results suggest that regular monitoring of obstacle-crossing kinematics for reduced toe-obstacle clearance or any signs of changes in crossing strategy may be helpful for early detection of compromised obstacle-crossing ability in patients with single-domain amnestic MCI. Further studies using a motor/cognitive dual-task approach on the kinematic strategies adopted by multiple-domain MCI will be needed for a complete picture of the functional adaptations in such a patient group

A neural network model for constructing endophenotypes of common complex diseases: an application to male young-onset hypertension microarray data

Motivation: Identification of disease-related genes using high-throughput microarray data is more difficult for complex diseases as compared with monogenic ones. We hypothesized that an endophenotype derived from transcriptional data is associated with a set of genes corresponding to a pathway cluster. We assumed that a complex disease is associated with multiple endophenotypes and can be induced by their up/downregulated gene expression patterns. Thus, a neural network model was adopted to simulate the gene–endophenotype–disease relationship in which endophenotypes were represented by hidden nodes

Roadmap on holography

From its inception holography has proven an extremely productive and attractive area of research. While specific technical applications give rise to 'hot topics', and three-dimensional (3D) visualisation comes in and out of fashion, the core principals involved continue to lead to exciting innovations in a wide range of areas. We humbly submit that it is impossible, in any journal document of this type, to fully reflect current and potential activity; however, our valiant contributors have produced a series of documents that go no small way to neatly capture progress across a wide range of core activities. As editors we have attempted to spread our net wide in order to illustrate the breadth of international activity. In relation to this we believe we have been at least partially successful.This work was supported by Ministerio de Economía, Industria y Competitividad (Spain) under projects FIS2017-82919-R (MINECO/AEI/FEDER, UE) and FIS2015-66570-P (MINECO/FEDER), and by Generalitat Valenciana (Spain) under project PROMETEO II/2015/015

Effect of ruthenium doping on the optical and photorefractive properties of Bi 12 TiO 20 single crystals

Abstract Bi 12 TiO 20 (BTO) single crystals nominally pure and doped with ruthenium are grown by top-seeded solution growth method. The effect of ruthenium concentration on optical and photorefractive properties is studied. Strong influence of doping on these properties is observed. It is shown that optical transmission of crystal samples with higher ruthenium content is shifted to the near IR spectral region, while the absorption coefficient is considerably increased. The optical activity of Ru doped crystals is further reduced in comparison with undoped BTO. Photochromic effect is observed in strongly doped crystal. Photorefractive properties are experimentally investigated using two-beam coupling. Response time and diffraction efficiency are changed with ruthenium content.

Global Hunger: A Challenge to Agricultural, Food, and Nutritional Sciences

Hunger has been a concern for generations and has continued to plague hundreds of millions of people around the world. Although many efforts have been devoted to reduce hunger, challenges such as growing competitions for natural resources, emerging climate changes and natural disasters, poverty, illiteracy, and diseases are posing threats to food security and intensifying the hunger crisis. Concerted efforts of scientists to improve agricultural and food productivity, technology, nutrition, and education are imperative to facilitate appropriate strategies for defeating hunger and malnutrition. This paper provides some aspects of world hunger issues and summarizes the efforts and measures aimed to alleviate food problems from the food and nutritional sciences perspectives. The prospects and constraints of some implemented strategies for alleviating hunger and achieving sustainable food security are also discussed. This comprehensive information source could provide insights into the development of a complementary framework for dealing with the global hunger issue

Effect of thermal-treatment sequence on sound absorbing and mechanical properties of porous sound-absorbing/thermal-insulating composites

Due to recent rapid commercial and industrial development, mechanical equipment is supplemented massively in the factory and thus mechanical operation causes noise which distresses living at home. In livelihood, neighborhood, transportation equipment, jobsite construction noises impact on quality of life not only factory noise. This study aims to preparation technique and property evaluation of porous sound-absorbing/thermal-insulating composites. Hollow three-dimensional crimp PET fibers blended with low-melting PET fibers were fabricated into hollow PET/low-melting PET nonwoven after opening, blending, carding, lapping and needle-bonding process. Then, hollow PET/low-melting PET nonwovens were laminated into sound-absorbing/thermal-insulating composites by changing sequence of needle-bonding and thermal-treatment. The optimal thermal-treated sequence was found by tensile strength, tearing strength, sound-absorbing coefficient and thermal conductivity coefficient tests of porous composites

Effect of thermal-treatment sequence on sound absorbing and mechanical properties of porous sound-absorbing/thermal-insulating composites

Due to recent rapid commercial and industrial development, mechanical equipment is supplemented massively in the factory and thus mechanical operation causes noise which distresses living at home. In livelihood, neighborhood, transportation equipment, jobsite construction noises impact on quality of life not only factory noise. This study aims to preparation technique and property evaluation of porous sound-absorbing/thermal-insulating composites. Hollow three-dimensional crimp PET fibers blended with low-melting PET fibers were fabricated into hollow PET/low-melting PET nonwoven after opening, blending, carding, lapping and needle-bonding process. Then, hollow PET/low-melting PET nonwovens were laminated into sound-absorbing/thermal-insulating composites by changing sequence of needle-bonding and thermal-treatment. The optimal thermal-treated sequence was found by tensile strength, tearing strength, sound-absorbing coefficient and thermal conductivity coefficient tests of porous composites